Class Subjects Major of Cognitive and Emotional Neuroscience

Outlines of Majors

Recently, incidence of dementia in longevity societies and problems due to emotional and behavioral abnormalities in juveniles are increasing. The brain is the only organ that develops during the lifetime under the influences of various factors such as many molecules produced from genes, the antenatal environment, and the environment of the external world after birth (social environment). Abnormalities in these material processes in the brain lead to emotional and behavioral abnormalities, while these emotional and behavioral abnormalities affect these material processes and change not only the brain structure but also the physiological functions. This major aims to develop sophisticated healthcare staff and leading brain scientists who can independently deal with mental problems and emotional/behavioral abnormalities, which are rapidly becoming problematic in developed countries, by overviewing them through interdisciplinary research approaches including specialized fields of basic medicine at the molecular, cellular, and system behavior levels as well as clinical medicine and human social sciences. The goal of this major is to establish science for humanity (“integrated science of the mind”), and the following items are targeted:

  • Neuroscience-based resolution of recognition/emotion/memory
  • Neuroscience in the development of emotional and mental behavioral disorders
  • Neuroscience in the development of higher brain dysfunction and development of preventive care
  • Establishment of molecular biological basis for brain development
  • Promotion of brain-scientific researches by utilizing the combined grounds of medical sciences and pharmaceutical sciences and drug discovery
  • Cross-sectoral analysis of neural information networks

List of Class Subjects

Educational area Responsible teacher Research contents
System Emotional Science Associate Professor NISHIMARU Hiroshi  Profile
  • Neural mechanisms of emotion, learning/memory, and behavioral expression in the limbic system
  • Neural mechanisms of social cognition and non-verbal communication
  • Non-invasive functional brain mapping of human higher brain functions
  • Neural mechanisms of stress and brain development
  • Central control of autonomic nervous functions
  • Neural mechanisms of chemical senses (taste and olfactory sensation)
Molecular Brain Science Professor INOKUCHI Kaoru  Profile

We aim to resolve mechanisms underlying memory formation and also roles played by idling brain in mammals by making full use of molecular biology, biochemistry, cell biology, histochemistry, electrophysiology, behavioral pharmacology, optogenetics, and live-imaging.

  • Research on the physical substance of engram
  • Research on the dynamics of engram
  • Research on idling brain functions
Molecular Neuroscience Professor MORI Hisashi  Profile


Associate Professor YOSHIDA Tomoyuki Profile

  • Research on molecular basis of higher brain functions such as cognition, emotion, and sociality with generation of novel genetically modified mouse models.
  • Research on the development of novel molecular imaging methods in the brain.
  • Research on molecular basis of neuro-immnune interactions.
  • Research on molecular mechanisms of central synapse formation.
  • Research on pathogenic mechanisms of neurodevelopmental disorders.
Integrative Neuroscience Professor TAMURA Ryoi Profile
  • Neural mechanisms of learning and memory in the hippocampal formation
  • Temporal coding in the hippocampal formation
  • Cortico-hippocampal interplay
  • Mechanism for memory consolidation in sleep
  • Functional analyses of eye movements
  • Mechanisms of gustatory information processing in the central nervous system
  • Adult neurogenesis
Molecular Neuropathology Professor SASAHARA Masakiyo(will be retired in March 2022) Profile
  • We aim to resolve the functional role of platelet-derived growth factor (PDGF) in various biological phenomena. We establish conditional knockout mouse models of PDGF receptors, and analyze these models and the cultured cells isolated from them. Cell biology and morphology are the major tools of our analyses.
  • Our studies are focusing on the coordination of higher brain function, and on the protection, repair and regenerative mechanism of nervous system. Fibroproliferative diseases and regenerative tissue responses are focused as well.
Neuropsychiatry Professor SUZUKI Michio Profile


Associate Professor TAKAHASHI Tsutomu Profile

  • Brain imaging studies on pathophysiology of schizophrenia and their application to objective diagnosis of psychotic disorders

  • Neurophysiological studies in schizophrenia and related disorders

  • Pharmacotherapy to improve cognitive dysfunction in schizophrenia

  • Mechanisms of symptom development and preventive strategies for schizophrenia

  • Mechanisms of brain maturation, personality development, and sociality in adolescence

  • Early diagnosis and intervention for dementia
Neurosurgery Professor  KURODA Satoshi Profile
  • Basic and clinical research on pathophysiology and treatment in cerebral ischemia
  • Clinical research on surgical technique and perioperative management in surgical revascularization
  • Basic and clinical research on neuroendovascular surgery
  • Basic and translational research on regenerative medicine in central nervous
  • Basic and clinical research on pathophysiology and surgical therapy of
  • Basic and clinical research on pathophysiology and surgical therapy in pediatric
  • Clinical research on multidisciplinary treatment for brain tumor
  • Basic and translational research on cancer stem cell in central nervous system
  • Clinical research on less invasive surgery by neuroendoscopy
  • Translational research on development of the devices for surgical procedure and functional recovery
Anatomy and Neuroscience Professor ICHIJO Hiroyuki Profile
  • Animals move toward favorable environments: feeding and mating, and escape from unfavorable stressful environments. These behaviors governed by specific neural circuits are selected through natural selection in evolution. Our purpose is to understand structure and function of neural circuits for the behaviors in evolutionary aspects.
  • Research on neural mechanisms of antero-posterior topography, left-right lateralization, and maturation of habenular nuclei under stress or aversive environments in mice.
  • Research on neural mechanisms of asymmetric behaviors in scale-eating cichlids.
  • Functional significance of individual difference in neuronal circuits of stress-processing.
  • Research on evolutionary mechanisms of animal innate behaviors in individual-based model simulation.
Clinical and Cognitive Neuroscience

Professor

 HAKAMATA Yuko

We aim at understanding the neurobiological mechanisms underlying emotional dysregulation associated with distorted cognitions, and using this understanding to develop novel, effective psychological interventions for anxiety and depressive disorders. We address these questions from the integrative view including psychology, cognitive behavioral science, endocrinology, immunology, genetics, and neuroscience. Lab members are expected to be engaged in research related to at least one of the following projects: 1) to examine the neurobiological mechanisms of biased cognitions towards emotional information; 2) to evaluate the efficacy of cognitive interventions including cognitive bias modification, cognitive training, and cognitive behavioral therapy for clinical and non-clinical population at high risk; and 3) to develop program tools to get the interventions easily accessible and doable. Participation in more than one project is encouraged.

 

Behavioral Physiology Professor TAKAO Keizo Profile Related site facebook

Investigation of the physiological basis of learning, memory, emotion, and cognition

Exploration and evaluation of mouse models of neuropsychiatric disorders using behavioral analyses

Elucidation of the pathophysiology and development of therapies for neuropsychiatric disorders using mouse models

Development of new genetically engineered mice

・Development of new reproductive technologies

Systems Function and Morphology

Professor

 ITO Tetsufumi

We employ multidisciplinary approach to investigate functional and morphological basis of the brain which allows the coding of sensory information, especially sounds, and the sensory perception. Followings are the examples of the approach.

(1) By combining neurophysiological and neuroanatomical techniques, the organization of neuronal circuitry which enable a specific function will be clarified.

(2) We will identify functional, morphological, and molecular details of neuronal cell types which constitute a neuronal circuitry to establish functional standpoint of each cell type.

(3) By comparing non-model animals which have unique specializations for sensory behaviors with model animals, details of the functional organization of sensory neuronal circuitry and its evolution will be clarified.

(4) By manipulating specific elements of a given neuronal circuitry, relationship between changes of activation patterns of the neuronal circuit and behavioral changes will be clarified.

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